abstract：:The mechanism of Cronobacter pathogenesis in neonatal meningitis and potential virulence factors (aside from host cell invasion ability) remain largely unknown. To ascertain whether Cronobacter can invade and transcytose across intestinal epithelial cells, enter into the blood stream and then transcytose across the bl...

journal_title：Microbial pathogenesis

authors： Giri CP,Shima K,Tall BD,Curtis S,Sathyamoorthy V,Hanisch B,Kim KS,Kopecko DJ

更新日期：2012-02-01 00:00:00

abstract：:Pathogenesis of Aeromonas species have been reported to be associated with virulence factors such as lipopolysaccharides (LPS), bacterial toxins, bacterial secretion systems, flagella, and other surface molecules. Dsb (Disulfide bond) proteins play an important role in catalyzing disulfide bond formation in proteins w...

journal_title：Microbial pathogenesis

authors： Vilches S,Jiménez N,Merino S,Tomás JM

更新日期：2012-02-01 00:00:00

abstract：:Bacillus anthracis secretes three major components, which assemble into two bipartite toxins: lethal toxin (LT), composed of lethal factor (LF) and protective antigen (PA) and edema toxin (ET), composed of edema factor (EF) and PA. EF is a potent calmodulin-dependent adenylate cyclase, which is internalized into the t...

journal_title：Microbial pathogenesis

authors： Levy H,Weiss S,Altboum Z,Schlomovitz J,Rothschild N,Glinert I,Sittner A,Kobiler D

更新日期：2012-01-01 00:00:00

abstract：:Roselle, or Jamaica sorrel (Hibiscus sabdariffa) is a popular vegetable in many tropical regions, cultivated for its leaves, seeds, stems and calyces which, the dried calyces are used to prepare tea, syrup, jams and jellies and as beverages. The main objectives of this study were to identify and characterise fungal pa...

journal_title：Microbial pathogenesis

authors： Eslaminejad T,Zakaria M

更新日期：2011-11-01 00:00:00

abstract：:To assess the role of mannosylated lipoarabinomannan (ManLAM) in the inflammatory and apoptotic response of mycobacteria-infected and uninfected, bystander cells we applied a mouse macrophage model of infection with avirulent strains--Mycobacterium bovis BCG, Mycobacterium tuberculosis (MTB) H37Ra and compared with a ...

journal_title：Microbial pathogenesis

authors： Wojtas B,Fijalkowska B,Wlodarczyk A,Schollenberger A,Niemialtowski M,Hamasur B,Pawlowski A,Krzyzowska M

更新日期：2011-07-01 00:00:00

abstract：:Besides the well characterized role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been implicated in virulence of pathogenic micro-organisms and because of its cell surface location, it has been shown to act as an adhesin for colonization of tissue surfaces both for pathogenic and non-pathogenic ...

journal_title：Microbial pathogenesis

authors： van der Merwe J,Prysliak T,Gerdts V,Perez-Casal J

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Rickettsia prowazekii is the etiological agent of epidemic typhus and is an obligate intracellular bacterium that grows as a parasite freely within the cytoplasm of a eukaryotic host cell. Previous studies have shown that rOmpA and rOmpB which belong to the family of rickettsial cell surface antigens are inv...

journal_title：Microbial pathogenesis

authors： Vellaiswamy M,Kowalczewska M,Merhej V,Nappez C,Vincentelli R,Renesto P,Raoult D

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to use fluorescence in-situ hybridisation (FISH) to search for the tissues and cell types important in survival and persistence of Mycoplasma haemofelis, "Candidatus Mycoplasma haemominutum" or "Candidatus Mycoplasma turicensis" in infected cats. A 16S rDNA probe for each species was applied ...

journal_title：Microbial pathogenesis

authors： Peters IR,Helps CR,Willi B,Hofmann-Lehmann R,Gruffydd-Jones TJ,Day MJ,Tasker S

更新日期：2011-02-01 00:00:00

abstract：:Outer surface protein E (OspE) is a complement factor H-binding virulence factor of borrelial subspecies. It is usually absent from in vitro grown Borrelia garinii, although in vivo B. garinii causes neuroborreliosis (NB). We analyzed the presence and sequence spectrum of the ospE genes in vivo in Borrelia spirochetes...

journal_title：Microbial pathogenesis

authors： Panelius J,Ranki A,Meri T,Seppälä I,Meri S

更新日期：2010-12-01 00:00:00

abstract：:Strains of the Enterobacter cloacae complex are becoming increasingly important human pathogen. The aim of the study was to identify, by sequencing the hsp60 gene, the species of clinical isolates phenotypically identified as E. cloacae and to examine them for virulence-associated properties: the ability of adhesion, ...

journal_title：Microbial pathogenesis

authors： Krzymińska S,Koczura R,Mokracka J,Puton T,Kaznowski A

更新日期：2010-09-01 00:00:00

abstract：:As a stationary-phase signal, indole is secreted in large quantities by Escherichia coli on enriched media and has been shown to control several genes; however, its impact on acid resistance remains to be studied in detail. Real-time quantitative reverse transcription-polymerase chain reaction analysis revealed that i...

journal_title：Microbial pathogenesis

authors： Hirakawa H,Hayashi-Nishino M,Yamaguchi A,Nishino K

更新日期：2010-09-01 00:00:00

abstract：:The Phytophthora capsici inflicts damage on numerous crop plants by secreting a series of pectinase including pectin methylesterase (PME). We identified a PME gene (pcpme6) from a genomic library of a highly virulent P. capsici strain SD33 which had an encoded a polypeptide of 348 amino acid residues with a predicted ...

journal_title：Microbial pathogenesis

authors： Feng B,Li P,Wang H,Zhang X

更新日期：2010-07-01 00:00:00

abstract：:The type III secretion system of Pseudomonas aeruginosa, responsible for acute infection, is composed of over twenty proteins that facilitate cytotoxin injection directly into host cells. Integral to this process is production and secretion of PcrV. Administration of a recently developed, anti-PcrV immunoglobulin, eit...

journal_title：Microbial pathogenesis

authors： Lynch SV,Flanagan JL,Sawa T,Fang A,Baek MS,Rubio-Mills A,Ajayi T,Yanagihara K,Hirakata Y,Kohno S,Misset B,Nguyen JC,Wiener-Kronish JP

更新日期：2010-06-01 00:00:00

abstract：:Streptococcus suis is an important pathogen in swine, and it also represents an emerging zoonotic agent. Zebrafish as a model for the evaluation of virulence of S. suis has been demonstrated before. Here, an Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish injected with S....

journal_title：Microbial pathogenesis

authors： Wu Z,Zhang W,Lu Y,Lu C

更新日期：2010-05-01 00:00:00

abstract：:Escherichia coli O157:H7 is a food-borne pathogen that can cause hemorrhagic colitis and, occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal failure and death. Here we sought to model the pathogenesis of orally-administered E. coli O157:H7 in BALB/c mice with an intact intestinal ...

journal_title：Microbial pathogenesis

authors： Mohawk KL,Melton-Celsa AR,Zangari T,Carroll EE,O'Brien AD

更新日期：2010-03-01 00:00:00

abstract：:It was recently shown that, as in yeast, alcohols selectively increase the hemolytic properties of certain staphylococci strains. This phenomenon has been called 'microbial alcohol-conferred hemolysis'(MACH). Here we present the changes in gene expression by Staphylococcus aureus 8325-4, in response to ethanol. Ethano...

journal_title：Microbial pathogenesis

authors： Korem M,Gov Y,Rosenberg M

更新日期：2010-02-01 00:00:00

abstract：:Staphylococcus aureus small-colony variants (SCVs) and biofilms are linked to chronic infections. It is known that the presence of aminoglycoside antibiotics may contribute to the emergence of SCVs and it is thought that molecular mechanisms are involved in the ability of S. aureus to adopt this phenotype. No study ha...

journal_title：Microbial pathogenesis

authors： Mitchell G,Brouillette E,Séguin DL,Asselin AE,Jacob CL,Malouin F

更新日期：2010-01-01 00:00:00

abstract：:Type VI secretion systems (T6SSs) have been identified recently in several Gram-negative organisms and have been shown to be associated with virulence in some bacterial pathogens. A T6SS of Yersinia pestis CO92 (locus YPO0499-YPO0516) was deleted followed by investigation of the phenotype of this mutation. We observed...

journal_title：Microbial pathogenesis

authors： Robinson JB,Telepnev MV,Zudina IV,Bouyer D,Montenieri JA,Bearden SW,Gage KL,Agar SL,Foltz SM,Chauhan S,Chopra AK,Motin VL

更新日期：2009-11-01 00:00:00

abstract：:The differences between the immune response elicited during a self-limiting and a life-threatening lung infection with Streptococcus pneumoniae was analyzed in a mouse model of intranasal challenge using two different pneumococcal strains. M10, a serotype 11A strain, induced an early response within the first 12h afte...

journal_title：Microbial pathogenesis

authors： Ferreira DM,Moreno AT,Cianciarullo AM,Ho PL,Oliveira ML,Miyaji EN

更新日期：2009-09-01 00:00:00

abstract：:Histophilus somni (H. somni) is a gram-negative bacterial pathogen that causes respiratory, reproductive, and central nervous system disease in cattle. The hallmark of systemic H. somni infection is diffused vasculitis that can lead to an acute central nervous system disease known as thrombotic meningoencephalitis (TM...

journal_title：Microbial pathogenesis

authors： Tiwari R,Sullivan J,Czuprynski CJ

更新日期：2009-09-01 00:00:00

abstract：:Xylella fastidiosa is a xylem-restricted plant pathogen that causes a range of diseases in several and important crops. Through comparative genomic sequence analysis many genes were identified and, among them, several potentially involved in plant-pathogen interaction. The experimental determination of the primary seq...

journal_title：Microbial pathogenesis

authors： Caruso CS,de Fátima Travensolo R,de Campus Bicudo R,de Macedo Lemos EG,Ulian de Araújo AP,Carrilho E

更新日期：2009-09-01 00:00:00

abstract：:Clostridium difficile causes serious and potentially fatal inflammatory diseases of the colon. Two large protein toxins, TcdA and TcdB, have been clearly implicated in pathogenesis. The goal of this study was to determine whether the glucosyltransferase activity of the toxins is critical for the induction of tumor nec...

journal_title：Microbial pathogenesis

authors： Sun X,He X,Tzipori S,Gerhard R,Feng H

更新日期：2009-06-01 00:00:00

abstract：:In this study experimental mouse model for Chlamydia pneumoniae infection was used to elucidate the nature of immune response developing during primary and secondary infection. First we examined the mononuclear cells from different lymphoid organs in BALB/c mice during C. pneumoniae infection and detected a strong lym...

journal_title：Microbial pathogenesis

authors： Kyläniemi MK,Haveri A,Vuola JM,Puolakkainen M,Lahesmaa R

更新日期：2009-05-01 00:00:00

abstract：:Respiratory infections caused by nontypeable Haemophilus influenzae (NTHi) are a major medical problem. Evidence suggests that the ability to form biofilms on mucosal surfaces may play a role in NTHi pathogenesis. However, the factors that contribute to NTHi biofilm cohesion remain largely unknown. In this study we in...

journal_title：Microbial pathogenesis

authors： Izano EA,Shah SM,Kaplan JB

更新日期：2009-04-01 00:00:00

abstract：:Like most microorganisms, Neisseria gonorrhoeae alters gene expression in response to iron availability. The ferric uptake regulator Fur has been shown to be involved in controlling this response, but the extent of this involvement remains unknown. It is known that in addition to working directly to repress gene expre...

journal_title：Microbial pathogenesis

authors： Ducey TF,Jackson L,Orvis J,Dyer DW

更新日期：2009-03-01 00:00:00

abstract：:A diarrheal isolate SSU of Aeromonas hydrophila produces a cytotoxic enterotoxin (Act) with cytotoxic, enterotoxic, and hemolytic activities. Our laboratory has characterized from the above Aeromonas strain, in addition to Act, the type 3- and T6-secretion systems and their effectors, as well as the genes shown to mod...

journal_title：Microbial pathogenesis

authors： Kozlova EV,Popov VL,Sha J,Foltz SM,Erova TE,Agar SL,Horneman AJ,Chopra AK

更新日期：2008-11-01 00:00:00

abstract：:E. coli infections in avian species have become an economic threat to the poultry industry worldwide. Several factors have been associated with the virulence of E. coli in avian hosts, but no specific virulence gene has been identified as being entirely responsible for the pathogenicity of avian pathogenic E. coli (AP...

journal_title：Microbial pathogenesis

authors： Antão EM,Glodde S,Li G,Sharifi R,Homeier T,Laturnus C,Diehl I,Bethe A,Philipp HC,Preisinger R,Wieler LH,Ewers C

更新日期：2008-11-01 00:00:00

abstract：:Pyelonephritis induces an inflammatory process in the renal parenchyma, which may occur as a result of excessive reactive nitrogen intermediates (RNI) and reactive oxygen species (ROS) and/or impaired antioxidant capacity. In the present investigation, contribution of free radicals to the development of acute pyelonep...

journal_title：Microbial pathogenesis

authors： Mittal R,Sharma S,Chhibber S,Harjai K

更新日期：2008-11-01 00:00:00

abstract：:Invasion plasmid antigen C (IpaC) is secreted by the Shigella flexneri type III secretion system (TTSS) as an essential trigger of epithelial cell invasion. At the molecular level, IpaC possesses a distinct functional organization. The IpaC C-terminal region between amino acids 319 and 345 is predicted to form a coile...

journal_title：Microbial pathogenesis

authors： Terry CM,Picking WL,Birket SE,Flentie K,Hoffman BM,Barker JR,Picking WD

更新日期：2008-10-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally. LuxS is known to be involved in the interspecies quorum sensing by mediating the production of AI-2 signal molecule and play important roles in regulating various behaviors of bacteria. In this...

journal_title：Microbial pathogenesis

authors： Li L,Zhou R,Li T,Kang M,Wan Y,Xu Z,Chen H

更新日期：2008-09-01 00:00:00

abstract：:In Salmonella enterica serovar Typhimurium, MgtC and PagC are positively regulated by the PhoP-PhoQ two-component system, which is activated under magnesium deprivation. Both MgtC and PagC are of unknown function but have been involved in intramacrophage survival. We have found that the amount of PagC is lowered in a ...

journal_title：Microbial pathogenesis

authors： Alix E,Miki T,Felix C,Rang C,Figueroa-Bossi N,Demettre E,Blanc-Potard AB

更新日期：2008-09-01 00:00:00

abstract：:Photobacterium damselae subsp. damselae has been known as an opportunistic pathogen in fish and mammals. Human infectious cases are often very serious and occasionally fatal. We previously reportedtwo fatal cases caused by this subspecies where the patients developed multiple organ failure within 20-36 h after the ons...

journal_title：Microbial pathogenesis

authors： Takahashi H,Miya S,Kimura B,Yamane K,Arakawa Y,Fujii T

更新日期：2008-08-01 00:00:00

abstract：:In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both e...

journal_title：Microbial pathogenesis

authors： Penttilä T,Haveri A,Tammiruusu A,Vuola JM,Lahesmaa R,Puolakkainen M

更新日期：2008-07-01 00:00:00

abstract：:Balamuthia amoebic encephalitis (BAE), caused by the protozoan pathogen, Balamuthia mandrillaris, is a serious human disease with fatal consequences and a mortality rate of more than 95%. A key factor that contributes to the high mortality is the incomplete understanding of its pathogenesis and pathophysiology. The mo...

journal_title：Microbial pathogenesis

authors： Siddiqui R,Khan NA

更新日期：2008-02-01 00:00:00

abstract：:An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. While wild type H. hepaticus cells could tolerate 6% O(2) for growth, the mdaB strain was cle...

journal_title：Microbial pathogenesis

authors： Hong Y,Wang G,Maier RJ

更新日期：2008-02-01 00:00:00

abstract：:Attenuated recombinant Listeria monocytogenes (Lm) strains are a promising class of vaccine vectors that trigger protective antigen-specific CD8 T cells. Listeriolysin O (LLO) is an important Lm virulence determinant allowing the bacterium to escape from the endocytic vacuole into the cell cytoplasm in phagocytic cell...

journal_title：Microbial pathogenesis

authors： Orgun NN,Way SS

更新日期：2008-02-01 00:00:00

abstract：:The Gram-positive bacterium Group B Streptococcus (GBS) is an important cause of serious neonatal and adult infections. Toll-like receptor 2 (TLR2) recognizes components of the cell wall of Gram-positive bacteria and is critical for defense against certain invasive pathogens. In GBS, penicillin-binding protein 1a (PBP...

journal_title：Microbial pathogenesis

authors： Asplin IR,Carl DJ,Way SS,Jones AL

更新日期：2008-01-01 00:00:00

abstract：:Microbial adherence to host cells is an early key step in the establishment of infection. During the course of Legionnaire's disease, Legionella interactions with host cells are best documented for resident macrophages. However, L. pneumophila can also replicate within type I and type II pneumocytes, which cover almos...

journal_title：Microbial pathogenesis

authors： Yaradou DF,Raze D,Ginevra C,Ader F,Doléans-Jordheim A,Vandenesch F,Menozzi FD,Etienne J,Jarraud S

更新日期：2007-11-01 00:00:00

abstract：:Enterococci are opportunistic pathogens known to cause numerous clinical infections and complications in humans. Adhesin-mediated binding to extracellular matrix (ECM) proteins of the host is thought to be a crucial step in the pathogenesis of these bacterial infections. Adhesin of collagen from Enterococcus faecalis ...

journal_title：Microbial pathogenesis

authors： Hall AE,Gorovits EL,Syribeys PJ,Domanski PJ,Ames BR,Chang CY,Vernachio JH,Patti JM,Hutchins JT

更新日期：2007-08-01 00:00:00

abstract：:The closely related Shiga toxins, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), can bind to Gb3 receptors. However, Stx2-producing enterohemorrhagic Escherichia coli (EHEC) strains are more commonly associated with serious human disease (viz., hemolytic-uremic syndrome) than Stx1-producing strains. To clarify the rel...

journal_title：Microbial pathogenesis

authors： Shimizu T,Sato T,Kawakami S,Ohta T,Noda M,Hamabata T

更新日期：2007-08-01 00:00:00